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GBP gene family in macrophages effects the immunotherapy in non-small cell lung cancer: mechanism and clinical study

Mechanisms of enhancing immunotherapy efficacy in non-small cell lung cancer mediated by GBP gene family in macrophages

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600128656
Enrollment
Unknown
Registered
2026-07-23
Start date
2026-08-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

Low GBP expression:None
High GBP expression:None

Sponsors

The First Affiliated Hospital of Kunming Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Age>=18 and < 75 years old; 2.Patients with newly diagnosed non-small cell lung cancer; 3.The first primary tumor was pathologically diagnosed as non-small cell lung cancer; 4.Subjects informed and consented to participate in the study;

Exclusion criteria

Exclusion criteria: 1.Clinical information was incomplete, including age, gender, treatment regimen, etc; 2.Systematic follow-up information was missing; 3.Patients with severe blood diseases, such as severe anemia, aplastic anemia, myelodysplastic syndrome, etc; 4.Due to poor physical condition, tumor pathological examination could not be performed to confirm the pathological diagnosis;

Design outcomes

Primary

MeasureTime frame
Overall Survival;Objective Response Rate;Disease Control Rate;Progression-Free Survival;

Secondary

MeasureTime frame
Adverse Event;Depth of Response;

Countries

China

Contacts

Public ContactZhao Yaqi

The First Affiliated Hospital of Kunming Medical University

Zhaoyaqi@kmmu.edu.cn+86 871 8750703

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 10, 2026