Idiopathic inflammatory myopathies
Conditions
Interventions
Idiopathic inflammatory myopathy without interstitial lung disease group:None
Idiopathic inflammatory myopathy with rapidly progressive interstitial lung disease group:None
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age >=18 years old; It conforms to the 2017 EULAR/ACR classification criteria for idiopathic inflammatory myopathy (IIM). It can complete baseline clinical data collection, laboratory tests, myositis antibody spectrum detection, HRCT, pulmonary function tests, multi-organ ultrasound and blood sample collection. Voluntarily participate in this study, sign the informed consent form, and agree to complete the follow-up.
Exclusion criteria
Exclusion criteria: Overlapping syndrome or combined with other definite connective tissue diseases; There are non-IIM-related lung diseases, such as occupational/environmental exposure-related ILD, drug-induced lung injury, radiation pneumonitis, pneumoconiosis, allergic pneumonia, sarcoidosis, etc. Combined active pulmonary infection, pulmonary tuberculosis, malignant lung tumors, severe COPD, bronchiectasis, pulmonary embolism, severe cardiac insufficiency or other diseases that can significantly affect the judgment of pulmonary outcomes; Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Molecular indicators of type I IFN pathway;Multimodal ultrasound and radiomics indicators;The first adverse pulmonary evolution event within 12 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under the receiver operating characteristic curve of the Transformer-based multimodal ultrasound model for diagnosing anti-MDA5-positive dermatomyositis-associated interstitial lung disease;Sensitivity of the model;Specificity of the model;Accuracy of the model; | — |
Countries
China
Contacts
Public ContactXin Yuwei
Peking University People's Hospital
Outcome results
None listed