Uveitis
Conditions
Interventions
Fluocinolone acetonide intravitreal implant group:0.18 mg fluocinolone sustained-release implant
Dexamethasone intravitreal implant group:0.7 mg dexamethasone implant
Sponsors
General Hospital of Central Theater Command, People's Liberation Army (PLA)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Clinically diagnosed with non-infectious uveitis involving the posterior segment, in accordance with the standards of the Standardisation of Uveitis Nomenclature (SUN) Working Group, with posterior segment involvement confirmed by fundus examination, fluorescein angiography (FFA) and optical coherence tomography (OCT), whilst infectious aetiologies have been ruled out; 3. Treated with FAi (single implantation) or DEX (repeated injections as required); 4. Had not previously received intravitreal corticosteroid implants prior to this indicated treatment; 5. Follow-up duration of >=12 months, with complete data on best-corrected visual acuity (BCVA), intraocular pressure (IOP), central macular thickness (CMT) and subfoveal choroidal thickness (SFCT) at baseline and at months 1, 3, 6 and 12.
Exclusion criteria
Exclusion criteria: 1. Infectious uveitis, including fungal, tuberculous or syphilitic uveitis; 2. Baseline intraocular pressure > 21 mmHg, a history of glaucoma, or evidence of glaucomatous optic neuropathy; 3. Significant opacities in the optical media that prevent adequate fundus imaging; 4. Incomplete follow-up data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 12-month recurrence rate of uveitis;Time to first recurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| best-corrected visual acuity ;central macular thickness;Number and interval of re-treatments;Proportion of patients with systemic corticosteroids / immunomodulatory therapy;Inflammation control rate; | — |
Countries
CHINA
Contacts
Public ContactZhang Wenjing
General Hospital of Central Theater Command, PLA
Outcome results
None listed