Early colorectal neoplasms located in the left-sided colon that are suitable for ESD resection
Conditions
Interventions
Local Clip Closure Group:After ESD, the wound is thoroughly irrigated and suctioned to clearly expose the base. Metal clips are then applied selectively and targetedly to visible vascular stumps, acti
Full-Layer Closure Group:After ESD, metal clips are used to perform appositional suturing starting from the margins of the wound using the mucosa-submucosa clip closure method. The aim is to achieve c
Sponsors
the Second Affiliated Hospital of Army Medical University,PLA
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Subjects must meet all of the following criteria: (1) Age >= 18 years and = 20 mm and <= 60 mm in size; (3) Lesion assessed as suitable for endoscopic submucosal dissection (ESD) by preoperative magnifying endoscopy or endoscopic ultrasound; (4) Patients who voluntarily agree to accept and comply with the trial protocol and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: Subjects who meet any of the following criteria will be excluded from the study: (1) Thrombocytopenia, coagulation disorders, or bleeding tendency (INR > 1.5, APTT > 1.5 times the upper limit of normal, or platelet count = 1000 µm; (3) Locally recurrent lesions after prior endoscopic resection; (4) Familial adenomatous polyposis or inflammatory bowel disease; (5) Concurrent severe diseases; psychiatric disorders; or poor compliance (e.g., inability to participate in postoperative follow-up); (6) Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delayed bleeding;Incidence of delayed perforation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of ESD procedure;Size of the resected specimen;Time required for wound closure/management);Total number of metal clips used;Postoperative abdominal pain score (VAS);Incidence of postoperative fever;Incidence of post-electrocoagulation syndrome, PECS;Length of postoperative hospital stay;Rate of emergency surgery or endoscopic intervention;Total medical cost related to the procedure; | — |
Countries
China
Contacts
Public ContactNie Xubiao
the Second Affiliated Hospital of Army Medical University,PLA
Outcome results
None listed