Postoperative Sleep Disorder
Conditions
Interventions
Esketamine group:Intraoperative low-dose esketamine
Control group:Intraoperative medium-dose normal saline
Sponsors
Jiaxing Maternal and Child Health Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 40–65 years; 2. ASA physical status classification I–III; 3. Body mass index ranging from 18 to 30 kg/m^2; 4. Scheduled for elective total laparoscopic hysterectomy (TLH) under general anesthesia; 5. Preoperative sleep disorder (Pittsburgh Sleep Quality Index [PSQI] > 7); 6. Signed informed consent obtained.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate; 2. Complicated with uncontrolled severe hypertension, coronary artery disease, cardiac insufficiency, pulmonary hypertension, cor pulmonale, elevated intracranial pressure, elevated intraocular pressure, or history of seizures; 3. Shift work; 4. Known allergy to esketamine or its excipients, or history of allergy to other anesthetics; 5. Long-term use of opioids or sedative-hypnotic drugs; 6. History of psychiatric disorders, neurological diseases, or previous/planned neurosurgical operations; 7. Hearing or visual impairment interfering with scale assessments adopted in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| N3 stage (deep sleep) duration on postoperative nights 1, 2 and 3; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective sleep quality;Total Sleep Time (TST), Sleep Efficiency (SE), and percentage of Wake After Sleep Onset (WASO%) on the preoperative night and postoperative nights 1, 2, and 3;Emotional state;Serum biomarkers; | — |
Countries
China
Contacts
Public ContactWang Yan
Jiaxing Maternity and Child Health Care Hospital
Outcome results
None listed