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Effect and Mechanism of Adalimumab-Loaded CeO2@mCS Nano Core–Shell Microspheres on hDPSCs-Mediated Dentin Regeneration under Inflammatory Conditions

Effect and Mechanism of Adalimumab-Loaded CeO2@mCS Nano Core–Shell Microspheres on hDPSCs-Mediated Dentin Regeneration under Inflammatory Conditions

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600128627
Enrollment
Unknown
Registered
2026-07-23
Start date
2026-08-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulpitis

Interventions

Sponsors

Beijing Stomatological Hospital , Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 25 Years

Inclusion criteria

Inclusion criteria: 1.Patients aged 18 to 25 years, regardless of gender. 2.Patients requiring extraction of impacted third molars.

Exclusion criteria

Exclusion criteria: 1.Presence of dental or periodontal disease on clinical examination. 2.Radiographs show root developmental anomalies or periapical lesions; 3.Patients with systemic diseases; 4.Contraindications to tooth extraction, including: Cardiac conditions: history of MI within 6 months or angina symptoms Hypertension: BP >180/100 mmHg Anemia: Hb usually 8.88 mmol/L Bleeding disorders, etc. 5. Women or lactating women; 6. People with mental or intellectual disabilities

Design outcomes

Primary

MeasureTime frame
The effect of CeO2@mCS on the activity of dental pulp stem cells;The effect of CeO2@mCS on the odontogenic/osteogenic differentiation of dental pulp stem cells;The effect of CeO2@mCS drug-free or drug-loaded on the antioxidant stress of dental pulp stem cells;Changes in anti-inflammatory and odontogenic/osteogenic differentiation-related indicators of dental pulp stem cells.;

Countries

China

Contacts

Public ContactShi Ruitang

Beijing Stomatological Hospital , Capital Medical University

shiruitang@126.com+86 10 57099232

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 10, 2026