Diarrhea-predominant irritable bowel syndrome
Conditions
Interventions
Multi-strain probiotic group:Subjects in the multi-strain probiotic group received a compound preparation containing multiple probiotic strains and resistant dextrin.
Placebo:Resistant dextrin
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–60 years, no gender restriction; 2.Meet the Rome IV diagnostic criteria for IBS-D; 3.Signed written informed consent;
Exclusion criteria
Exclusion criteria: 1.Presence of infectious diarrhea or drug-induced diarrhea; 2.Suffering from inflammatory bowel disease, antibiotic-associated diarrhea or other similar gastrointestinal disorders; 3.Pregnant or breastfeeding women; 4.Subjects with gastrointestinal hemorrhage; 5.Organic intestinal diseases (e.g., colon cancer, inflammatory bowel disease, etc.); 6.History of gastrointestinal surgery; 7.Concomitant use of drugs known to affect gastrointestinal motility; 8.Administration of antibiotics or probiotics within the past two weeks; 9.Subjects who fail to consume the test product as required or miss scheduled follow-ups, rendering efficacy unevaluable; 10.Any subjects deemed unsuitable for participation by the investigators for other reasons;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptoms of subjects with IBS-D; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut microbiota;Safety indicators;Quality of life; | — |
Countries
China
Contacts
Public ContactZhou Tao
Qilu Hospital of Shandong University
Outcome results
None listed