Upper tract urothelial carcinoma
Conditions
Interventions
Kidney-sparing group:None
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed or recurrent upper tract urothelial carcinoma (UTUC) suspected by preoperative imaging, such as CT urography or MR urography, and preliminary ureteroscopic examination; 2. Radiological evidence of cT1-2N0M0 UTUC, with kidney-sparing endoscopic treatment planned; 3. Aged 18 years or older, regardless of sex; 4. Able to provide written informed consent, willing to comply with the study protocol, and able to complete follow-up.
Exclusion criteria
Exclusion criteria: 1. Radiological evidence of locally advanced , cN+, or cM1 disease; 2. Contraindications to ureteroscopic surgery, such as severe cardiovascular disease or an uncorrectable coagulation disorder; 3. Severe uncontrolled urinary tract infection; 4. History of another malignancy or receipt of other anticancer treatment within the previous five years; 5. Concurrent urinary or genital malignancy, such as renal cancer or prostate cancer; 6. Participation in a drug clinical trial within three months before enrollment; 7. Any condition considered by the investigator likely to increase participant risk or interfere with study conduct; 8. Incomplete specimens or clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reportability rate of basal resection margin status; | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessability rate of pathological T stage;Interobserver agreement among pathologists;Tumor grade reportability rate;Specimen quality-related indicators;Interpretability rate of basal invasion status;Perioperative safety; | — |
Countries
China
Contacts
Public ContactGengyan Xiong
Peking University First Hospital
Outcome results
None listed