Esophageal Squamous Cell Carcinoma
Conditions
Interventions
Adjacent normal group:None
Sponsors
Huai'an First People's Hospital
Eligibility
Sex/Gender
All
Age
51 Years to 81 Years
Inclusion criteria
Inclusion criteria: 1. All participants aged 18 to 90 years voluntarily enrolled in this study and provided written informed consent; 2. All patients were newly diagnosed with esophageal squamous cell carcinoma (ESCC) and underwent surgical resection, with no prior treatments including chemotherapy, radiotherapy, targeted therapy or biotherapy; 3. All participants provided complete baseline medical records, including detailed medical history, imaging data and preoperative laboratory test results.
Exclusion criteria
Exclusion criteria: 1. Patients diagnosed with two or more malignant tumors; 2. Patients with documented active bacterial or fungal infections, congenital or acquired immunodeficiencies, or autoimmune diseases within the past month; 3. Patients who had used antibiotics, probiotics or antifungal drugs at least two months prior to tissue collection; 4. Patients with organic cardiovascular diseases, infectious diseases, reflux esophagitis or recurrent esophageal cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bacterial and fungal community structures and differential species in tumor and paracancerous tissues; | — |
Secondary
| Measure | Time frame |
|---|---|
| Core modules of multi-dimensional interaction network among microbiota, metabolites and transcripts;Spatial colocalization of core microorganisms and host cells; | — |
Countries
China
Contacts
Public ContactYong Gao
Huai'an First People's Hospital
Outcome results
None listed