Radiation enteritis
Conditions
Interventions
Combined treatment subgroup:Vitamin C combined with dexamethasone
Prevention group:Intravenous injection of vitamin C
The subgroup for simple treatment:0.9% sodium chloride and dexamethasone
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients with a clinically and pathologically confirmed diagnosis of rectal cancer who are scheduled to receive radiotherapy; 2.Expected survival > 1 year; 3.First-time radiotherapy; 4.Aged between 18 and 80 years; 5.Agree to participate in the trial and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1.Deficiency of glucose-6-phosphate dehydrogenase (G-6-PD); 2.Allergy to vitamin C; 3.Intestinal failure or short bowel syndrome of any etiology; 4.Related intestinal diseases (inflammatory bowel disease, celiac disease, Whipple's disease); 5.Renal insufficiency; 6.Urinary calculi (urolithiasis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptom relief rate;The incidence rate of radioactive enteritis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of inflammatory factors;Level of immune cells;Degree of mucosal injury; | — |
Countries
China
Contacts
Public ContactLin Dandan
Renmin Hospital of Wuhan University
Outcome results
None listed