Obese
Conditions
Interventions
Multi-strain Probiotics Group:Multi-strain Probiotics
Probiotic group:Bifidobacterium adolescentis HY03596
B420 Positive Control Group:Probiotic B420
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Female subjects aged 18–65 years; 2.Body mass index (BMI) ranging from 24.0 to 28.0 kg/m^²; 3.Waist-to-hip ratio >= 0.83; 4.No intake of any products that may affect body weight or gut microbiota (e.g., probiotics, prebiotics, dietary supplements) or medications (e.g., antihypertensives, lipid-lowering drugs, weight-loss drugs) within the past month; 5.Willing to receive and complete all study-related examinations, including finger-prick blood sampling and venous blood collection; 6.Voluntary participation, capable of understanding study procedures and signing the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Organic intestinal diseases (e.g., colon cancer, inflammatory bowel disease, short bowel syndrome, etc.); 2.Subjects diagnosed with diabetes mellitus; 3.Use of antibiotics, antifungals or probiotic preparations within the past month; 4.Administration of any drugs or injections that may directly affect body weight within the past three months (e.g., orlistat, GLP-1 receptor agonists such as liraglutide/semaglutide, metformin used for weight loss, other anti-obesity medications, etc.); 5.Concomitant severe cardiac, cerebral, renal or hepatic diseases (e.g., heart failure, stroke, chronic renal insufficiency, active liver disease, etc.); 6.Individuals with chronic excessive alcohol consumption (>20 g per day) or a history of alcohol abuse; 7.Subjects with psychiatric or cognitive disorders who are unable to comply with trial procedures; 8.Long-term or continuous use of medications known to markedly disrupt gut microbiota homeostasis (e.g., long-term systemic glucocorticoids, immunosuppressants, chronic maintenance broad-spectrum antibiotics, etc.); 9.Pregnant women or those planning to become pregnant within the next six months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anthropometric parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| quality of life indicators;safety indicators;mood state indicators;biochemical indicators; | — |
Countries
China
Contacts
Public ContactLixiang Li
Qilu Hospital of Shandong University
Outcome results
None listed