Chemotherapy-Related Cognitive Impairment in Breast Cancer
Conditions
Interventions
Healthy control group:None
Sponsors
Yancheng Third People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Breast Cancer Chemotherapy Group: Female patients who underwent modified radical mastectomy for breast cancer and whose postoperative pathological results were invasive ductal carcinoma of the breast (stages I-III); no targeted therapy, immunotherapy, or radiotherapy before chemotherapy; right-handed; able to understand and cooperate with the neuropsychological assessment; aged 18-75 years; without MRI examination contraindications, able to cooperate with the MRI examination; within 1 month after chemotherapy, developed CRCI [MoCA score <= 25 points]. 2. Healthy Control Group: Previously healthy, without history of neurological diseases and normal cognitive function assessment; no MRI examination contraindications, able to cooperate with the MRI examination; right-handed; aged 18-75 years.
Exclusion criteria
Exclusion criteria: 1. Breast cancer chemotherapy group: Cognitive function assessment was abnormal before chemotherapy; organic diseases that affected data analysis were detected by routine MRI; image rotation > 2° or displacement > 2 mm. 2. Healthy control group: Organic diseases that affected data analysis were detected by routine MRI; MRI image rotation > 2° or displacement > 2 mm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA) Score;Functional Magnetic Resonance Imaging (fMRI) Brain Function Index;Functional Assessment of Cancer Therapy–Cognitive Function(FACT-cog);Self-Rating Depression Scale(SDS);Self-Rating Anxiety Scale(SAS);TNF-a; INF-?; IL-2; IL-5; IL-6; IL-17A; IL-10; IL-12P70; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age;Gender;Educational duration; | — |
Countries
China
Contacts
Public ContactHaiyan Wu
Yancheng Third People's Hospital
Outcome results
None listed