Parkinson's disease and/or cognitive impairment
Conditions
Interventions
Transcranial light stimulation group:Transcranial light stimulation group
Sponsors
The Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged 50 years or older; 2.Parkinson’s disease group: Patients with clinically definite Parkinson’s disease according to the latest revised diagnostic criteria issued by the International Parkinson and Movement Disorder Society (MDS), with Hoehn and Yahr stage 1–3;Cognitive impairment group: Patients diagnosed with mild cognitive impairment (MCI) or Alzheimer’s disease (AD) based on internationally and nationally recognized diagnostic criteria; 3.Clinically stable condition, with a stable medication regimen in the past 4 weeks and no definite plan for major adjustment during the study period; 4.Meet the relevant safety criteria for examinations and procedures if receiving non-invasive neuromodulation intervention; 5.Able to understand the purpose and procedures of the study, voluntarily participate in this clinical trial, and have signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Presence of other severe neurological diseases (e.g., stroke sequelae, brain tumor, inflammatory demyelinating disease) or severe mental disorders that may interfere with clinical assessment; 2.History of epilepsy or at high risk of convulsions; 3.Contraindications to MRI/EEG examinations (e.g., implanted devices incompatible with MRI, severe claustrophobia precluding scanning); 4.Severe unstable medical conditions (e.g., decompensated heart/respiratory failure, severe hepatic or renal insufficiency); 5.Participation in other clinical trials that may interfere with the evaluation of primary endpoints, or receipt of systematic neuromodulation therapy within the past 1 month (defined specifically in each sub-study).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parkinson's disease rating scale score;Mini-Mental State Examination (MMSE) score;Montreal Cognitive Assessment (MoCA) score; | — |
Countries
China
Contacts
Public ContactChunfeng Liu
The Second Affiliated Hospital of Soochow University
Outcome results
None listed