Gastrointestinal discomfort
Conditions
Interventions
Part Two: Fentanyl combined with cyclopofol group:Fentanyl 1 µ g/kg+0.4mg/kg cyclopofol
Part Two: Oxycodone group combined with cyclopofol group:Oxycodone + cyclopofol: Part One Research Results
Part Two: Normal Saline group combined with cyclopofol group:2ml of normal saline +0.5mg/kg cyclopofol
Part one : 01 group:Oxycodone (0.05mg/kg) + cyclopofol (0.5mg/kg)
Part one : 02 group:Oxycodone (0.075mg/kg) + cyclopofol (0.4mg/kg)
Part one : 03 group:Oxycodone (0.1mg/kg) + cyclopofol (0.3mg/kg)
Sponsors
Peking University International Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age range: >=18 and20 and < 30.
Exclusion criteria
Exclusion criteria: 1.History of neurological disorders or mental illness; 2.History of anesthesia surgery within the past month; 3.Long-term use of analgesic drugs; 4.Uncontrolled hypertension, arrhythmia, and heart failure and other medical histories; 5. History of obstructive sleep apnea (OSA), acute upper respiratory tract infection, asthma and other respiratory diseases; 6.History of anesthetic drug allergy; 7. Long-term heavy drinking; 8.Coagulation dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative hypoxemia in patients;Body movement response;Coughing response; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Pulse oximetry;Modified observer’s assessment of alert;Blood pressure;degree of satisfaction;Total dosage of medication;Awakening time;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactYao Lan
Peking University International Hospital
Outcome results
None listed