Cardiac light-chain amyloidosis (AL-CA), heart failure, myocardial amyloid deposition, myocardial interstitial fibrosis, cardiac damage associated with plasma cell disorders
Conditions
Interventions
Patients with light-chain cardiac amyloidosis:None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with confirmed diagnosis of AL-CA(immunoglobulin light-chain cadiac amyloidosis); 2.Have signed written informed consent for the preliminary clinical study; 3.Be willing to and capable of complying with the specified study procedures;
Exclusion criteria
Exclusion criteria: 1.Poor-quality or incomplete imaging data; 2.Failure to meet the inclusion/exclusion criteria; 3.Patient withdrawal of informed consent; 4.Failure of the patient to comply with study procedures; 5.The investigator determines that withdrawal is in the patient’s best interest;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Semi-quantitative score of myocardial interstitial fibrosis;Semi-quantitative score of myocardial amyloid deposition;Discriminative performance of prognostic model (C-index, time-dependent AUC); | — |
Countries
China
Contacts
Public ContactLi Huo
Peking Union Medical College Hospital
Outcome results
None listed