pulmonary fibrosis
Conditions
Interventions
Pulmonary fibrosis control group:None (observational study)
Non-pulmonary fibrosis control group:None (observational study)
Sponsors
The first affiliated hospital of anhui medical university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged >=18 years, no gender restriction; 2.Diagnosed with pulmonary fibrosis by imaging and/or pathology (fibrosis group); or without pulmonary fibrosis (control group); 3.Able to provide at least one of the following samples: peripheral blood, bronchoalveolar lavage fluid, or lung tissue; 4.Voluntarily sign informed consent;
Exclusion criteria
Exclusion criteria: 1.Concurrent active infection, malignancy, or other severe organ disease; 2.Pregnant or breastfeeding women; 3.Inadequate sample quality (e.g., severe hemolysis); 4.Considered unsuitable for participation by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SAMHD1 protein expression and localization in lung tissue (IHC);Proportion of SAMHD1-positive monocytes/macrophages in bronchoalveolar lavage fluid (flow cytometry);SAMHD1 mRNA expression level in lung tissue (qPCR);FN1 protein level in lung tissue (Western blot);SAMHD1 protein level in lung tissue (Western blot);a-SMA protein level in lung tissue (Western blot);Proportion of SAMHD1-positive monocytes/macrophages in peripheral blood (flow cytometry); | — |
Countries
China
Contacts
Public ContactShen Qiying
The first affiliated hospital of anhui medical university
Outcome results
None listed