Lung cancer
Conditions
Interventions
Gold Standard:According to the diagnostic workflow for lung cancer outlined in the Clinical Practice Guidelines for Lung Cancer Diagnosis and Treatment of the Chinese Medical Association (2020 Edition
Index test:QCL-based VOCs detection system (prototype), Mid-infrared cavity ring-down spectroscopy (CRDS), Formaldehyde, Isoprene, Acetone, Pathological diagnosis (gold standard), Gas chromatography-m
Sponsors
Cancer Hospital, Chinese Academy of Medical Sciences, Shenzhen Center
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Age >=18 years, both sexes; Meet one of the following: lung cancer cohort, benign lung disease cohort, healthy controls;The subject or their authorized representative signs the informed consent form.
Exclusion criteria
Exclusion criteria: Comorbid other malignant tumors; severe hepatic or renal dysfunction, infectious diseases, or severe infections; major psychiatric disorders or significant cognitive impairment; inability to cooperate with the breath test; pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area Under the Receiver Operating Characteristic Curve (AUC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Positive Predictive Value (PPV);Negative Predictive Value (NPV);Exhaled volatile organic compound (VOC) concentrations;Serum tumor markers (CEA, NSE, CYFRA21-1); | — |
Countries
China
Contacts
Public ContactDuan Boshi
Cancer Hospital, Chinese Academy of Medical Sciences, Shenzhen Center
Outcome results
None listed