Intraoperative cough reflex
Conditions
Interventions
Thoracic vagus nerve block group:Injection of 5 mL of 2% lidocaine at the thoracic vagus nerve under thoracoscopic guidance.
Cervical vagus nerve block group:Injection of 5 mL of 2% lidocaine at the cervical vagus nerve under ultrasound guidance.
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged 18–65 years at the time of enrollment; 2. Body mass index (BMI) < 26 kg/m²; 3. Pulmonary tumor, with a maximum tumor diameter < 6 cm, and no evidence of endobronchial involvement or distant metastasis; 4. American Society of Anesthesiologists (ASA) Physical Status classification I–II; 5. Written informed consent obtained prior to any study-related procedures.
Exclusion criteria
Exclusion criteria: 1. History of prior pulmonary resection, or presence of cardiac insufficiency (e.g., left ventricular ejection fraction [LVEF] < 40%); 2. Recent use of anticoagulants (e.g., within the past 3 months) or known coagulation disorders/coagulopathy; 3. Known allergy or hypersensitivity to local anesthetics, opioids, or any other study-related medications used in the procedures; 4. Severe pleural adhesions suggested on preoperative imaging; 5. Any other condition deemed by the investigator to render the participant unsuitable for enrollment (e.g., pregnancy, lactation, psychiatric disorders, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative cough (grade 2–4);Severity of intraoperative cough (grade 1–4); | — |
Secondary
| Measure | Time frame |
|---|---|
| Surgical duration;Postoperative complications (dyspnea, sore throat, nausea/vomiting, incision pain, fever, pulmonary infection);Intraoperative arterial blood gas (PaCO2, pH);Incidence of intraoperative hypoxemia/desaturation;Incidence of intraoperative hypotension;Total anesthetic drug consumption (propofol, remifentanil, sufentanil, dexmedetomidine);Number of rescue opioid administrations due to cough/movement;Intraoperative blood loss;Anesthesia duration;Block-related complications (hoarseness, Horner’s syndrome, intravascular injection/hematoma);Emergence time;Intraoperative hemodynamic and ventilation stability (MAP, HR, RR, SpO2, PetCO2);Block procedure time;Postoperative length of hospital stay;Time to first ambulation after surgery;Anesthesia preparation time;Intraoperative limb movement grade (1–4);Chest tube placement; | — |
Countries
China
Contacts
Public ContactSu Yongjun
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed