Post-induction hypotension
Conditions
Interventions
Norepinephrine Group:Propofol induction begins simultaneously with continuous infusion of low-dose norepinephrine. Norepinephrine was continuously infused at 0.03 µg/kg/min until 15 minutes after the
Saline Control Group:Propofol induction is initiated simultaneously with the infusion of an equal volume of normal saline. In case of hypotension, rescue and blood pressure increase are provided accor
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 65 years; 2.Scheduled to undergo elective non-cardiac surgery under general anesthesia with endotracheal intubation or laryngeal mask airway (LMA); 3.American Society of Anesthesiologists (ASA) physical status class II or III; 4.Planned insertion of a radial artery catheter for continuous arterial pressure monitoring; 5.An anticipated observation window of at least 10–15 minutes between propofol induction and skin incision; 6.Stable Doppler ultrasound signals obtainable for both the carotid and brachial arteries; 7.Able to provide written informed consent;
Exclusion criteria
Exclusion criteria: 1.Bilateral carotid artery stenosis greater than 50% or known severe cerebrovascular stenosis; 2.Severe peripheral arterial disease, upper extremity arterial occlusion, presence of a dialysis fistula, or a history of upper limb vascular surgery; 3.Severe cardiac arrhythmias (e.g., rapid atrial fibrillation, frequent premature ventricular contractions) that affect arterial pressure waveform or Doppler analysis; 4.Left ventricular ejection fraction less than 40% or severe heart failure; 5.Severe aortic stenosis or severe valvular regurgitation; 6.Preoperative shock, current use of vasoactive drugs, or significant hemodynamic instability; 7.Uncontrolled severe hypertension; 8.Contraindications to propofol, fat emulsion, norepinephrine, or related medications; 9.Failure of radial artery catheterization; 10.Inability to obtain stable ultrasound signals for the carotid or brachial arteries; 11.Any other conditions deemed unsuitable for study enrollment by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve (AUC) for the relative decrease in carotid artery cMD from the B2 baseline within 15 minutes after the initiation of propofol administration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Carotid blood flow parameters;Brachial artery blood flow indicators;Continuous arterial pressure and conventional hemodynamic indicators;Anesthesia depth and respiratory-related indicators;Security Index; | — |
Countries
China
Contacts
Public ContactZhou Yang
Peking University Third Hospital
Outcome results
None listed