Pulmonary Aspergillosis
Conditions
Interventions
Gold Standard:Proven Case:
Identification of Aspergillus hyphae via microscopy or culture from needle aspiration or biopsy specimens obtained from a sterile site, accompanied by tissue damage
or culture of Aspergillus from sterile samples collected from the lesion site
or detection of Aspergillus DNA in formalin-fixed, paraffin-embedded tissues through PCR amplification and sequencing.
Clinically Diagnosed Case:
Must meet at least one criterion from each of the foll
Index test:Galactomannan (GM) Antigen
PCR
Culture
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Strong clinical suspicion of pulmonary aspergillosis based on a comprehensive assessment of symptoms, signs, and imaging by a clinician; 3.Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Individuals unable to cooperate with the study or provide informed consent; 3.Cases where clinical data are expected to be insufficient for final diagnostic grouping.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Galactomannan (GM) Antigen;Aspergillus-specific IgG;Aspergillus Polymerase Chain Reaction;(1,3)-ß-D-Glucan Detection Assay;Chest CT;Microbial Culture; | — |
Countries
China
Contacts
Public ContactXiang Tong
West China Hospital of Sichuan University
Outcome results
None listed