Obstructive sleep apnea syndrome
Conditions
Interventions
Surgery Effective Group:None
Surgery Ineffective Group:None
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University (Sun Yat-sen University Hospital of Hepatology)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old, gender not restricted; 2. Diagnosed with OSA by overnight polysomnography (PSG): Apnea Hypopnea Index (AHI) >= 5 times per hour; 3. Confirmed as having normal blood pressure by 24-hour ambulatory blood pressure monitoring (ABPM): 24-hour average systolic blood pressure = 10% lower than the average daytime blood pressure; 5. Has anatomical upper airway obstruction as assessed by otolaryngology and meets the indications for UPPP surgery; 6. Voluntarily participates in the study and signs a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Previous or current use of any antihypertensive medication; 2. Prior or current treatment with CPAP or other OSA-related therapies; 3. Presence of other sleep disorders (e.g., central sleep apnea, insomnia, restless legs syndrome); 4. Presence of severe, uncontrolled medical conditions (e.g., malignancy, renal failure, chronic obstructive pulmonary disease, severe depression); 5. Contraindications for UPPP surgery (e.g., severe coagulopathy, velopharyngeal insufficiency, unstable cardiovascular status); 6. Pregnant or breastfeeding women; 7. Participants deemed by the investigator to have social or geographic factors that may affect follow-up compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in nocturnal mean diastolic blood pressure (DBP); | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in 24-hour, daytime, and nighttime mean systolic blood pressure (SBP) and 24-hour and daytime mean diastolic blood pressure (DBP);Change in 24-hour, daytime, and nighttime blood pressure variability (standard deviation);Change in daytime sleepiness score (Epworth Sleepiness Scale);Change in quality of life questionnaire scores (e.g., SF-36 or Calgary Sleep Apnea Quality of Life Index);Change in fasting glucose, lipid profile, and other biochemical parameters; | — |
Countries
China
Contacts
Public ContactLiu Weixing
The Third Affiliated Hospital of Sun Yat-sen University (Sun Yat-sen University Hospital of Hepatology)
Outcome results
None listed