Knee osteoarthritis
Conditions
Interventions
Trial Group:Conventional rehabilitation training combined with repetitive peripheral magnetic stimulation (rPMS) intervention. rPMS parameters: pulse frequency 20Hz, stimulation duration 2s, intermiss
Control Group:Conventional rehabilitation training combined with sham repetitive peripheral magnetic stimulation (rPMS) intervention. Sham stimulation uses the same equipment and coil placement, but o
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnostic criteria for knee osteoarthritis (KOA) according to the Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2024 edition): (1) Recurrent knee pain within the past month; (2) Age >= 50 years; (3) Morning stiffness lasting = 5 repetitions, indicating tolerance to light-to-moderate intensity training; 11. Unilateral KOA, with the affected side clearly identified as the primary symptomatic side and the contralateral side showing no significant pain or functional impairment; 12. Cognitive status and compliance: alert, with normal comprehension ability; 13. able to complete all training and assessments according to the study protocol; 14. Informed consent: fully understanding the purpose and procedures of the study and voluntarily signing a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe knee deformity or instability (e.g., Kellgren-Lawrence grade IV osteoarthritis, or candidates for joint replacement); 2. Active lesions such as acute ligament rupture, fracture, synovitis, or septic arthritis; 3. Prior knee surgery or intra-articular injection therapy (e.g., corticosteroids) within the past 3 months; 4. Concurrent severe cardiovascular, cerebrovascular, respiratory, or metabolic diseases that preclude tolerance of rehabilitation training; 5. Peripheral vascular disease, uncontrolled hypertension, history of thrombosis, or coagulation abnormalities; 6. Neurological disorders (e.g., peripheral neuropathy, Parkinson's disease, stroke sequelae) causing lower limb motor impairment; 7. Severe cognitive impairment, psychiatric disorders, or poor compliance, making it impossible to complete the study procedures; 8. Skin lesions, subcutaneous infections, or any conditions that interfere with electrode attachment; 9. Presence of metallic implants in the treatment area, or implantation of a cardiac pacemaker, implantable cardioverter-defibrillator, insulin pump, or similar devices; 10. Use of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or muscle relaxants within 4 weeks prior to enrollment, or the need to continue taking such medications that may interfere with neuromuscular function during the study period; 11. Severe obesity (BMI > 35 kg/m^2) that prevents completion of training; 12. Participation in other clinical trials that could potentially confound the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Knee Injury and Osteoarthritis Outcome Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle strength;30?second chair stand test;The Short-From-36 Health Survey, SF-36;Visual Analog Scale for Pain(VAS);Knee range of motion;Surface electromyography (sEMG) parameters; | — |
Countries
China
Contacts
Public ContactSun Limin
Huashan Hospital, Fudan University
Outcome results
None listed