Parkinson's Disease
Conditions
Interventions
TMS group:Both coils will simultaneously stimulate the left DLPFC and left cerebellum. The stimulation will be administered for 5 consecutive days per week, over two consecutive weeks, totaling 10 ses
TMS-sham group:The coil is positioned at 90 degrees to the head, producing only sound without an effective magnetic field, while all other procedures are identical to those in theTMS group.
Health Group:none
Sponsors
Beijing Rehabilitation Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. PD patients: (1) Meet the diagnostic criteria of the Chinese Guidelines for the Treatment of Parkinson's Disease (Third Edition); (2) Hoehn-Yahr stage I–IV; (3) Aged 30–70 years, any gender, right-handed; (4) In the "ON" state, with a stable medication regimen for at least 4 weeks. For stage IV patients, the following additional conditions must be met: 1) Able to walk 10 meters independently or with a walking aid, without requiring physical assistance from others; 2) Able to independently complete tablet-based drawing tasks; 3) No more than 2 falls in the past 3 months. 2. Healthy subjects: (1) Healthy individuals in good physical condition; (2) Aged 30–70 years, any gender.
Exclusion criteria
Exclusion criteria: 1.PD patients: (1) Those with various secondary Parkinson's syndromes and Parkinson's plus syndromes; (2) Dysfunction of vital organs such as the heart, liver, kidneys, or the hematopoietic system, as well as moderate to severe primary diseases of the endocrine system; (3) Severe infections or severe complications of diabetes mellitus; (4) Schizophrenia, Alzheimer's disease, vascular dementia, or cognitive impairment caused by other conditions. 2.Healthy subjects: Those with a history of neurological diseases, severe physical illnesses, or mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dual-Task Cost; | — |
Secondary
| Measure | Time frame |
|---|---|
| MDS-UPDRS-III;Digit Symbol Substitution Test;Stroop Color-Word Test;Cognitive-Motor Dual-Task Assessment;Functional magnetic resonance imaging, fMRI;Functional near-infrared spectroscopy, fNIRS; | — |
Countries
China
Contacts
Public ContactHuang Peiling
Beijing Rehabilitation Hospital Affiliated to Capital Medical University
Outcome results
None listed