Infection-associated thrombocytopenia
Conditions
Interventions
recombinant human thrombopoietin (rhTPO):None
historical control group(Conventional treatment):None
Sponsors
Shandong Provincial Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. (1) PLT = 30 x 10^9/L from the platelet count measured 48 hours earlier. 3. The patient or their legal guardian has signed the informed consent form, demonstrates good compliance, and is willing to cooperate with follow-up visits.
Exclusion criteria
Exclusion criteria: 1.Known history of allergy to rhTPO. 2.History of thrombosis or bleeding disorders. 3.Pregnancy or breastfeeding, or inability to take effective contraceptive measures during the study period. 4.Participation in another clinical study involving platelet-elevating agents within 14 days prior to screening. 5.Contraindication to any required concomitant medication or supportive therapy. 6.Concurrent severe hematological diseases (e.g., aplastic anemia, myelodysplastic syndrome, leukemia, etc.). 7.End-stage hepatic or renal failure, hematopoietic system disorders, or malignant tumors. 8.Thrombocytopenia caused by other factors, such as chemotherapy/radiotherapy-related thrombocytopenia, massive hemorrhage, or immune thrombocytopenia (ITP). 9.Any active severe psychiatric disorder, medical condition, or other situation that, in the investigator‘s judgment, may affect treatment adherence, compliance, or the ability to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time required for platelet count to recover to = 100 × 10^9/L; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence rate of adverse events;30?day survival rate after discharge;improvement in bleeding events;Day 7 Platelet Relative Change Rate;Platelet transfusion rate (frequency and quantity);Total efficiency (CR + R); | — |
Countries
China
Contacts
Public ContactSun Liang
Shandong Provincial Third Hospital
Outcome results
None listed