undergoing major abdominal surgery for various indications
Conditions
Interventions
Ciprofol:Anaesthetic induction: Administer 0.3–0.5 mg/kg of cyclobutolol intravenously
assess the Modified Observer Alertness/Sedation Score (MOAA/S) and the eyelash reflex every 30 seconds following administration. When the MOAA/S is <=1 (i.e. no response to mild stimulation or shaking
Propofol:Anaesthetic induction: Administer propofol 1.5–2.5 mg/kg intravenously
assess the Modified Observer Alertness/Sedation Score (MOAA/S) and eyelash reflex every 30 seconds following administration. When the MOAA/S score is <=1 (i.e. no response to mild stimulation or shaki
Sponsors
zhongda hospital southeast university
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1)American Society of Anesthesiologists (ASA) physical status classification I–III; 2) Age 65 years or older; 3) Scheduled for major abdominal surgery under general anesthesia (expected duration of surgery >= 2 hours, including, but not limited to, gastrointestinal, hepatobiliary, pancreatic, splenic, retroperitoneal, or other major intra-abdominal surgeries).
Exclusion criteria
Exclusion criteria: 1) Contraindications for drug use: allergy to propofol or cyclopropofol; long-term (>6 months) use of benzodiazepines or opioids; administration of a2-adrenergic agonists or other sedatives within 24 hours prior to surgery; 2) Body mass index (BMI) below 18.5 or above 29.9 kg/m²; 3) Severe hepatic or renal dysfunction: Child-Pugh class B or C; estimated glomerular filtration rate (eGFR) 180 mmHg or diastolic blood pressure>110 mmHg); myocardial infarction or unstable angina within the past 3 months; 5) Neurological disorders (Alzheimer's disease, Parkinson's disease, previous stroke with neurological deficits, history of epilepsy, or current use of antiepileptic drugs); 6) Previous surgery within the past 3 months; 7) Minor abdominal surgeries with low postoperative complication risk, including renal surgery, simple abdominal wall or body surface surgery, inguinal hernia repair, diagnostic laparoscopy, simple appendectomy, or simple cholecystectomy; as well as day surgeries or procedures not requiring postoperative hospitalization observation; 8) Participation in other competing clinical trials or refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Troponin levels;nausea and vomitting;Brain electrical spectrum characteristics;Blood pressure remains stable within 15 minutes after anesthesia induction.;Complications of a single system;MAP?HR;emergence time, time to discharge from the PACU after extubation, and postoperative hospitalization duration;Cardiac output indicator(CO?CI?SVR?SVRI?SV?SVI?SVV?PPV?HRV);Incidence of intraoperative hypotension (SBP or MAP less than 20 per cent of baseline), hypertension (SBP or MAP more than 20 per cent above baseline) and bradycardia (HR less than 50 beats per minute); | — |
Countries
China
Contacts
Public ContactSun Jie
zhongda hospital southeast university
Outcome results
None listed