subclinical cardiovascular impairment
Conditions
Interventions
Experimental Group:Take probiotic capsules
Sponsors
Beijing Prevention and Treatment Hospital of Occupational Disease(Beijing Institute of Occupational Disease Prevention and Treatment)
Eligibility
Sex/Gender
Male
Age
30 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Has been working full-time as a designated driver for over 6 consecutive months, is currently still in this job, and has no other part-time work; 2. Male, aged between 30 and 45; 3. Night shift work and hours: mainly night shifts (working at least 5 days a week, with at least 4 hours between 10:00 PM and 6:00 AM), weekly working hours between 40 and 55; 4. Voluntarily willing to participate in this study and able to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of cardiovascular disease and risk factors (including atherosclerosis, myocardial infarction, heart failure, hypertension, high cholesterol, overweight or obesity, etc.), currently taking medications for cardiovascular disease; 2. History of major diseases in other systems (including severe digestive system, urinary system, immune system diseases, etc.); 3. Currently having digestive system problems such as diarrhea, constipation, gastric ulcer, duodenal ulcer, etc.; 4. History of using antibiotics, probiotics, or medications for digestive system diseases in the past 3 months; 5. History of smoking or drinking; 6. Any other situation judged by the researcher as unsuitable for participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota structure and metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biomarkers: ET-1, heart-type fatty acid-binding protein, high-sensitivity cardiac troponin I, N-terminal pro-B-type natriuretic peptide; | — |
Countries
China
Contacts
Public ContactTenglong Yan
Beijing Prevention and Treatment Hospital of Occupational Disease(Beijing Institute of Occupational Disease Prevention and Treatment)
Outcome results
None listed