Nervous System Diseases
Conditions
Interventions
Observation group:None
Sponsors
923 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with chronic subdural hematoma (CSDH) via cranial CT or MRI and scheduled for burr hole drainage; 2. Aged 18 years or older; 3. Complete clinical data available, and capable of cooperating with sample collection and follow-up.
Exclusion criteria
Exclusion criteria: 1. Combined with severe hepatic or renal insufficiency, malignant tumors, or autoimmune diseases; 2. Received antibiotics, probiotics or prebiotic preparations within 3 months before surgery; 3. Complicated with intestinal diseases (e.g., inflammatory bowel disease, irritable bowel syndrome); 4. Patients unable to complete follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hematoma recurrence rate;Relative abundance of SCFA-producing genera including Lachnospira, Bifidobacterium, Roseburia;Metabolic Indicators; Inflammatory Indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale (mRS) score;MGS-GCS grading;Nakaguchi CT classification of chronic subdural hematoma;Safety indicators including postoperative infection incidence, gastrointestinal symptoms, etc.;fecal microbiota alpha diversity;fecal microbiota beta diversity; | — |
Countries
China
Contacts
Public ContactYan Geng
923 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army
Outcome results
None listed