Metabolic dysfunction–associated fatty liver disease
Conditions
Interventions
PNL group:Parthenolide (PNL) dietary supplementation
Sponsors
The Hong Kong Polytechnic University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1 Chinese adults 2 Aged 35–60 years 3 BMI > 24 kg/m^² 4 Diagnosed with non-alcoholic fatty liver disease (hepatic fat =5%) by MRI-PDFF or clinical assessment 5 Willing to provide written informed consent
Exclusion criteria
Exclusion criteria: 1 Viral hepatitis 2 Excessive alcohol consumption (>210 g/week for men; >140 g/week for women) 3 Use of steatogenic, anti-diabetic, weight-reducing, CYP3A4 substrate, or anticoagulant/antiplatelet drugs 4 Participation in other clinical trials 5 Presence of diabetes, hypertension, severe dyslipidemia, or other metabolic disorders 6 Pregnancy or breastfeeding 7 Metal implants incompatible with MRI or claustrophobia 8 Known allergy to plants in the Compositae family (e.g., ragweed, chrysanthemum)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrahepatic fat content (MRI-PDFF); | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Mass Index (BMI);Waist circumference;Waist-to-hip ratio;Serum liver function parameters (ALT, AST);Serum triglycerides and total cholesterol; | — |
Countries
China
Contacts
Public ContactZhu Yuyan
Department of Food Science and Nutrition The Hong Kong Polytechnic University
Outcome results
None listed