Study on the efficacy of artificial ossicle implantation in patients with hereditary bilateral conductive hearing loss based on whole-exome sequencing

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600128468

Enrollment

Unknown

Registered

2026-07-21

Start date

2026-08-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital middle ear malformation

Interventions

WES identified a human population with clearly pathogenic/potentially pathogenic gene variants.:None

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with bilateral symmetric conductive hearing loss who are hospitalized in our department and have air-bone conduction difference >=35dB HL; 2. Ear CT examination was performed in our hospital before surgery; 3. Patients receiving artificial ossicle implantation; 4. Patients can be regularly visited for hearing and CT examination after surgery; 5. Voluntarily accept genetic testing;

Exclusion criteria

Exclusion criteria: 1. Does not meet the above selection criteria; 2. Clinical audiology or imaging data are missing or unclear, or the results are of poor quality; 3. Patients diagnosed with secretory otitis media, cerumen embolism, middle ear cholesteatoma, otosclerosis and other ear diseases that can cause conductive deafness;

Design outcomes

Primary

Measure	Time frame
Audiology indicators such as PTA and ABG;Temporal bone CT;genetic test results;	—

Secondary

Measure	Time frame
Auditory deformity;postoperative complications;	—

Countries

China

Contacts

Public ContactLiu Yuhe

Beijing Friendship Hospital ,Capital Medical University

liuyuhefeng@163.com+86 10 8357 2315

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 10, 2026