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Clinical efficacy evaluation of xenogeneic collagen matrix in aesthetic zone implantation guided bone regeneration and simultaneous soft tissue increment: a prospective randomized controlled clinical trial

Clinical efficacy evaluation of xenogeneic collagen matrix in aesthetic zone implantation guided bone regeneration and simultaneous soft tissue increment: a prospective randomized controlled clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600128466
Enrollment
Unknown
Registered
2026-07-21
Start date
2026-07-24
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with insufficient volume of adjacent implant sites or bridge sites supported by fixed implants in the anterior maxilla are allowed to undergo horizontal GBR during implantation

Interventions

Experimental group:Xenogeneic collagen matrix
control group:None

Sponsors

Yantai Stomatological Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.The maxillary anterior region exhibits the condition of either two adjacent missing teeth or multiple missing teeth, for which fixed implant-supported restoration is planned. 2.A horizontal bone defect is present, necessitating the concurrent implementation of GBR during the surgical procedure. 3. The soft tissue exhibits a thin gingival biotype, which necessitates concurrent soft tissue augmentation during the surgical procedure. 4. The adjacent teeth are intact with no prosthesis. 5.All subjects' ages ranged from 20 to 70 years. 6.Possess a thorough understanding of the nature of this research and voluntarily execute the informed consent document.

Exclusion criteria

Exclusion criteria: 1.Having systemic diseases that affect the ability of tissue healing 9such as uncontrolled diabetes). 2. Heavy smoking (smoking more than 20 cigarettes per day). 3.Currently receiving treatment with immunosuppressants, bisphosphonates, or high-dose corticosteroids. 4.Unable to cooperate in completing follow-up examinations. 5.A vertical bone defect is present.

Design outcomes

Primary

MeasureTime frame
Contour of labial soft tissue;Mucosal thickness on the labial side;

Secondary

MeasureTime frame
Height of the interproximal gingival papilla;Marginal bone level around the dental implant;Width of the keratinized mucosa at the labial aspect;Volume of labial soft tissue;White esthetic score;Pink esthetic score;

Countries

China

Contacts

Public ContactWenjuan Zhou

Yantai Stomatological Hospital

zhouwenjuan1004@163.com+86 535 6601027

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 10, 2026