Neurocritical illness, sepsis, acute pancreatitis
Conditions
Interventions
Neurocritical Care Group (Stress Group):none
Early Severe Acute Pancreatitis Group (Stress-Inflammation Group):none
Sepsis Group (Stress-Infection Group):none
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Overall patient inclusion criteria (all potential ICU subjects must first meet the following overall criteria before proceeding to group-specific screening): Age >=18 years; admitted to the ICU due to acute illness with an expected length of stay >72 hours; first ultrasound assessment can be completed within 12 hours after ICU admission; not receiving any cardioactive drugs (digoxin, milrinone, dopamine, dobutamine, levosimendan, recombinant human brain natriuretic peptide, beta-blockers, epinephrine, isoproterenol, etc.). 2. Overall inclusion criteria for healthy subjects: Age 18-80 years. 3. Neurocritical care group (stress group): Primary diagnosis of severe traumatic brain injury (GCS =IV), or extensive cerebral infarction (infarct size >2/3 of the middle cerebral artery territory). Inflammatory level: procalcitonin (PCT) <=1 ng/mL at enrollment, with no clinical or microbiological evidence of co-existing infection. 4. Sepsis group (stress-infection group): Patients admitted to the ICU with a primary diagnosis of sepsis according to the Sepsis-3 international consensus criteria. 5. Early severe acute pancreatitis group (stress-inflammation group): Primary diagnosis meeting the criteria for severe acute pancreatitis according to the Revised Atlanta Classification, onset within 1 week, and procalcitonin (PCT) <=1 ng/mL at enrollment. 6. Healthy control group: Healthy volunteers matched by age and sex to the neurocritical care, sepsis, and early severe acute pancreatitis subgroups.
Exclusion criteria
Exclusion criteria: 1.Overall exclusion criteria for patients: (1) Previous history of heart disease: Including but not limited to severe coronary heart disease (previous history of myocardial infarction, coronary artery bypass or stent implantation), moderate or severe heart valve disease, cardiomyopathy, chronic heart failure (NYHA cardiac function >= grade III), after permanent pacemaker or ICD implantation, and severe arrhythmias (such as persistent atrial fibrillation, second and third degree atrioventricular block, etc.); (2) Other severe chronic organ dysfunction: including chronic obstructive pulmonary disease (COPD GOLD >= grade 3), chronic liver disease (Child-Pugh grade C), and chronic kidney disease (eGFR < 30 mL/min/1.73m^2); (3) Poor image quality: The image quality of transthoracic echocardiography is poor and fails to meet the analysis requirements of at least two core ultrasound techniques (STE, VFM, cCEUS). (4) Pregnant or lactating women; 2. Overall exclusion criteria for healthy subjects: A history of severe heart disease (such as severe coronary heart disease, cardiomyopathy, chronic heart failure, severe arrhythmia, etc.); There are other severe chronic organ dysfunctions that seriously affect prognosis; Pregnant or lactating women. 3. Neurocritical illness group (Stress Group) : No additional exclusion criteria. 4. Sepsis group (Stress-infection group) : Severe craniocerebral injury (GCS <= 12 points) is the main diagnosis or coexisting disease. 5. Early severe acute pancreatitis group (stress-inflammation group) : Severe craniocerebral injury (GCS <= 12 points) is the main diagnosis or coexisting disease; 6. Healthy control group: Individuals with any known history of cardiovascular diseases, chronic diseases, or acute conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vector Flow Mapping (VFM);Myocardial Contrast Echocardiography (cEUS);Speckle Tracking Echocardiography (STE);Routine Clinical Information;Conventional Echocardiographic Parameters;Autonomic Function Monitoring Information;Prognostic Outcome Measures: In-hospital mortality, 28-day mortality, ICU length of stay, duration of mechanical ventilation, total treatment cost.; | — |
Countries
China
Contacts
Public ContactYin Wanhong
West China Hospital of Sichuan University
Outcome results
None listed