Autism spectrum disorder
Conditions
Interventions
Control group:Intensive intervention based on applied behavior analysis (ABA), including basic parent education/training in ABA.
Experimental group:ABA combined with parent-implemented naturalistic developmental behavioral intervention (NDBI), primarily delivered through the Project ImPACT model.
Sponsors
Children's Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
1 Years to 8 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the DSM-5 diagnostic criteria for Autism Spectrum Disorder, with an Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) comparison score of >= 7, as confirmed by a multidisciplinary clinical team. 2. The primary caregiver (providing >= 20 hours of weekly companionship) is able to communicate in Mandarin, can understand the study content, provide written informed consent, and has no serious psychiatric or psychological disorders (e.g., major depressive disorder).
Exclusion criteria
Exclusion criteria: 1. Comorbid severe neurological disorders or unstable physical illnesses that would interfere with study participation. 2. Severe visual, auditory, or motor impairments that would affect the implementation of assessments/training. 3. Participation in other clinical trials or receipt of high-intensity, similarly structured programs within the past 6 months that could influence the outcomes of the present study. 4. Poor compliance as judged by the investigator, rendering the participant unable to complete the intervention according to the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Scale Assessments; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain Function Assessment; | — |
Countries
China
Contacts
Public ContactChenxi Li
Children's Hospital, Zhejiang University School of Medicine
Outcome results
None listed