None
Conditions
Interventions
Experimental Group:Nebulized dexmedetomidine (2 µg/kg) plus 2% lidocaine, total volume 4 mL
Control Group:Nebulized 4 mL normal saline
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Age 3-12 years old; 2. Elective tonsillectomy, with or without adenoidectomy; 3. ASA classification I or II; 4. The child's legal guardian voluntarily participates in this study and signs a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Known allergy to dexmedetomidine, lidocaine, or any component of their formulations; 2. Severe heart, lung, liver, or kidney dysfunction; 3. Severe neurological disorders (like uncontrolled epilepsy or intellectual disability) or mental illness that prevents cooperation with assessment; 4. Recent (within 2 weeks) severe respiratory infection; 5. Expected difficult airway (modified Mallampati class IV, limited mouth opening, etc.); 6. Patients expected to need ICU care after surgery; 7. Use of drugs affecting sedation or pain assessment (like sedatives or analgesics) within 24 hours before surgery; 8. Already participating in another study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of total perioperative respiratory adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters;Postoperative length of stay;Incidence of individual perioperative respiratory adverse events;Early postoperative pain scores;The incidence of adverse events, including bradycardia, hypotension, and postoperative nausea and vomiting;Incidence of emergence agitation; | — |
Countries
China
Contacts
Public ContactChen Lijian
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed