Severe neutropenia in cancer patients after chemotherapy
Conditions
Interventions
Observation group:None
Sponsors
Xi'an Daxing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 80 years old, gender not restricted; 2. Diagnosed with malignant tumor and receiving chemotherapy treatment in our hospital; 3. Has complete basic clinical data and relevant laboratory test results before chemotherapy; 4. Has blood routine test results within 7 - 14 days after chemotherapy, which can determine whether grade 3 or above neutropenia occurs; 5. Medical records are complete and can meet the needs of research analysis; 6. The same patient is only included in the first chemotherapy cycle to avoid repeated inclusion.
Exclusion criteria
Exclusion criteria: 1. Those who had ANC < 1.0×10^9/L before chemotherapy; 2. Those with concurrent hematological diseases or clear abnormalities in bone marrow hematopoietic function; 3. Those with acute infections, severe inflammatory reactions or febrile diseases; 4. Those who have received other treatments in the recent period that may significantly affect bone marrow function and whose effects cannot be distinguished, such as those who have used white blood cell stimulants/hormones within the last 4 weeks and whose bone marrow function has been affected; 5. Those whose blood routine results are missing 7-14 days after chemotherapy and cannot determine the main outcome; 6. Those with severe lack of key clinical data or laboratory examination data, which cannot meet the needs of research analysis; 7. Pregnant or lactating patients; 8. Those whose test time window does not match, whose chemotherapy and pre-chemotherapy conditions are inconsistent, or whose extreme values cannot be verified.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of severe neutropenia within 7–14 days after chemotherapy; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein level;proportion of CD28-positive T cells ; CD4/CD8 ratio;Interferon-gamma, IFN-?;Systemic immune-inflammation index, SII;White blood cell count,WBC;Tumor necrosis factor-alpha, TNF-a;Hemoglobin,Hb; interleukin-10 level ;Platelet count, PLT;Platelet-to-lymphocyte ratio, PLR;Lymphocyte count,LYM;proportion of PD-1-positive T cells ;Absolute neutrophil count,ANC;Monocyte-to-lymphocyte ratio, MLR;Neutrophil-to-lymphocyte ratio, NLR;Monocyte count, MONO; interleukin-6 level; | — |
Countries
China
Contacts
Public ContactJINGJING TIE
Xi'an Daxing Hospital
Outcome results
None listed