Severe Fever with Thrombocytopenia Syndrome (SFTS)
Conditions
Interventions
Standard-dose IVIG group (SOC + IVIG 20g/d):Standardized symptomatic and supportive treatment for severe SFTS plus standard-dose IVIG
Low-dose IVIG group (SOC + IVIG 10g/d):Standardized symptomatic and supportive treatment for severe SFTS combined with low-dose IVIG
Control group (SOC + Placebo):Standardized symptomatic and supportive treatment for severe SFTS plus normal saline placebo
Sponsors
The first affiliated hospital of anhui medical university
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 75 years old with no gender restriction; 2. Confirmed diagnosis of SFTS, disease course no more than 7 days, and positive SFTSV RNA test result; 3. Severe case criteria: platelet count less than 50×10?/L accompanied by organ damage or disturbance of consciousness; 4. Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe liver and kidney failure, malignant tumors, autoimmune diseases and severe infections; 2. Previous use of IVIG, immunosuppressive or immunostimulant drugs; 3. Pregnant or lactating women; 4. Allergy to IVIG or its excipients; 5. Failure to cooperate with follow-up visits or incomplete medical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day case fatality rate;Incidence rate of adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of IL-6 and IFN-?;SFTSV viral load;Platelet recovery time; | — |
Countries
China
Contacts
Public ContactHu Lifen
The first affiliated hospital of anhui medical university
Outcome results
None listed