None
Conditions
Interventions
D group:After general anesthesia induction, during the control of breathing, 2% tetracaine 50mg and 1µg/kg dexmedetomidine were aerosolized and inhaled together, totaling 2.5ml.
C group:After general anesthesia induction, 2.5 ml of 0.9% normal saline was inhaled through nebulization during respiratory control.
Sponsors
Hefei First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 18 - 65 years old. Gender: Open to all. 2.Patients scheduled for general anesthesia and requiring oral tracheal intubation for surgical procedures; 3.American Society of Anesthesiologists (ASA) classification: grades I to III; 4.The patient's vital signs were stable before the operation, and there were no significant abnormalities in routine examinations such as liver and kidney function, coagulation function, and electrocardiogram. 5.The estimated duration of the surgery is 30 minutes to 3 hours. During the perioperative period, relevant indicators can be monitored and follow-up can be conducted in conjunction. 6.The patients and their families were fully informed about the content of this study, the intervention methods and the risks involved. They voluntarily participated in this study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.There are individuals who have had allergic reactions to surface anesthesia drugs such as lidocaine and ropivacaine, or who have an allergic constitution. 2.Those with severe underlying diseases of the heart, liver, kidneys, lungs, and central nervous system, and who are unable to tolerate tracheal intubation and anesthesia procedures; 3.Those who have preoperative airway diseases such as airway hyperresponsiveness, acute asthma attacks, chronic obstructive pulmonary disease, sore throat, airway edema, and airway malformations; 4.Those who had used sedatives, analgesics, muscle relaxants, or drugs that affect hemodynamics or airway reactivity within 24 hours before the operation; 5.Patients with a history of difficulty in tracheal intubation and those with high-risk for difficult airway assessment; 6.Combine patients with coagulation dysfunction, autoimmune diseases, malignant tumors and severe infections; 7.Pregnant and lactating women; 8.Mental disorders, cognitive dysfunction, unable to cooperate with the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| diastolic blood pressure;systolic blood pressure;heart rate; | — |
Countries
China
Contacts
Public ContactSun Hao
Hefei First People's Hospital
Outcome results
None listed