schizophrenia
Conditions
Interventions
Traditional Target Group:Implant intracranial electrodes and ablate the traditional targets, the anterior limb of the internal capsule and the claustrum.
Image Fusion Target Group:Combine PET and MRI fusion data to implant intracranial electrodes and ablate the target.
normal imaging control group:MRI, 18F-FDG-PET, 18F-DOPA-PET
Sponsors
The First Affiliated Hospital of Shantou University Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Schizophrenia treatment group: 1. The patient has a diagnosis and a history of formal medication use for more than 3 years, has been treated with clozapine, and meets the criteria for drug-refractory schizophrenia. 2. The patient initially responded well to dopamine receptor blockers but showed poor subsequent response. 3. The patient has paranoid schizophrenia, with symptoms primarily characterized by intermittent auditory or visual hallucinations, and is aged between 18 and 40 years. 4. The patient exhibits normal communication abilities, with no significant impairment in cognitive function or intelligence. 5. The patient demonstrates good treatment compliance, high family cooperation, and strong willingness for treatment from both the patient and family members. According to the regulations of the hospital’s medical ethics committee regarding psychosurgical procedures, the efficacy of the surgery and the risks of complications were explained in detail. Both the patient and family members acknowledged the information provided and signed the informed consent form. Normal imaging control group: Aged 18–40 years; no history of schizophrenia or any other psychiatric disorders; no prior use of psychotropic medications.
Exclusion criteria
Exclusion criteria: Schizophrenia treatment group: 1. Severe impairment in cognitive abilities and intellectual level, language dysfunction, or vision impairment; 2. Presence of violent tendencies or self-harming behaviors; 3. Inability to tolerate surgery due to poor physical condition or other reasons; 4. Conditions such as claustrophobia that prevent cooperation with PET or MRI examinations. Normal imaging control group: Exclusion criteria include abnormal liver and renal function, claustrophobia, implanted metallic devices and other contraindications; subjects shall have indications for PET examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale (PANSS) score;Brief Psychiatric Rating Scale (BPRS) score;Clinical Global Impression (CGI) score;Scale for the Assessment of Positive Symptoms (SAPS) score;Scale for the Assessment of Negative Symptoms (SANS) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Three-Factor Eating Questionnaire (TFEQ) score;Behavioral Activation System - Reward Responsiveness (BAS-R) score;Beck Depression Inventory (BDI) score;Barratt Impulsiveness Scale (BIS-11) score;Modified Overt Aggression Scale (MOAS) score;Launay-Slade Hallucination Scale (LSHS) score;Social Disability Screening Schedule (SDSS) score;Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score;Montreal Cognitive Assessment (MoCA) score;Mini-Mental State Examination (MMSE) score; | — |
Countries
China
Contacts
Public ContactNaili Wei
The First Affiliated Hospital of Shantou University Medical College
Outcome results
None listed