Weight management for mental patients
Conditions
Interventions
Group A:Semaglutide (subcutaneously injected once a week, with a dose titrated from 0.25mg to 1.7mg per week) + regular diet and exercise intervention.
Group B:Orlistat (120 mg each time, taken three times a day with meals) + regular diet and exercise intervention.
Group C:Conventional diet and exercise intervention (control group). Diet: A nutritionist customizes a low-calorie diet (with a daily deficit of 500kcal)
Exercise: 30 minutes of moderate-intensity aerobic exercise daily (such as walking, resistance training)
Sponsors
The 984th Hospital of the Joint Logistic Support Force of the People's Liberation Army of China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age: 18-65; Inpatients in the psychiatry department (schizophrenia, bipolar disorder, depression); Have taken antipsychotic drugs for at least 3 months; BMI>=27 kg/m^2 and combined with obesity-related diseases, or BMI>=30kg/m^²; Sign informed consent.
Exclusion criteria
Exclusion criteria: Severe physical illness combined with liver, kidney and brain dysfunction; Severe metabolic disorder; Having used weight-loss drugs or undergone surgery within 90 days; History of acute and chronic pancreatitis; History of medullary thyroid carcinoma Currently participating in other weight loss trials; Eating disorders; History of pregnancy, lactation and drug allergy; Type 1 diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of weight loss after 12 weeks (compared to baseline); | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight;Waist circumference;Hip circumference;BMI (Body Mass Index);Body fat percentage;Blood lipid;systolic pressure;Fasting blood glucose;Mental scale assessment;TESS Scale (Self-Rating Depression Scale); | — |
Countries
China
Contacts
Public ContactShi Xiufang
The 984th Hospital of the Joint Logistic Support Force of the People's Liberation Army of China
Outcome results
None listed