Obsessive-Compulsive Disorder
Conditions
Interventions
Real-world control group:none
Control group:Transcranial Magnetic Stimulation (Sham Stimulation)
Healthy Control Group:none
Sponsors
The Second Xiangya Hospital of CSU
Eligibility
Sex/Gender
All
Age
16 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for study participants (experimental group, drug follow-up group): 1. Be capable of providing informed consent to participate in the clinical trial and have signed a dated informed consent form. 2. Be willing to comply with all study procedures and be able to attend imaging examinations, clinical evaluations, and treatments as required during the study. 3. Be between the ages of 16 and 45. 4. Have a primary diagnosis of obsessive-compulsive disorder (OCD) according to the criteria in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR; American Psychiatric Association, 2022), with a primary diagnosis of obsessive-compulsive disorder (OCD). 5. A Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) total score of >= 16, or a subscale score of >= 10. 6. Poor response to standard treatment for OCD. 7. Diagnosis of OCD for more than 12 months. Inclusion criteria for the healthy control group: 1. No history of any psychiatric disorders.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for study participants (experimental group, drug follow-up group): 1. The study participant is pregnant or planning to become pregnant. 2. The study participant has been diagnosed with a psychotic disorder. 3. The study participant has experienced a manic episode. 4. The study participant has had a spontaneous epileptic seizure. 5. The study participant has a neurological disorder. 6. The study participant has a history of traumatic brain injury. 7. The study participant currently has a substance use disorder or alcohol/drug abuse issues (excluding tobacco). 8. The study participant has any contraindications to magnetic resonance imaging (MRI) scans. Regarding criterion 4, seizures induced by electroconvulsive therapy (ECT) are not considered spontaneous seizures and are therefore not included in the exclusion criteria. The clinical investigator will assess the study participant’s history of ECT and determine eligibility based on this assessment. Exclusion Criteria for the Healthy Control Group: 1. The participant is pregnant or planning to become pregnant. 2. The participant has a history of manic episodes. 3. The participant has a history of spontaneous seizures. 4. The participant has a neurological disorder. 5. The participant has a history of traumatic brain injury. 6. The participant currently has a substance use disorder or alcohol/drug abuse issues (excluding tobacco). 7. The participant has any contraindications to magnetic resonance imaging (MRI) scans.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the severity of obsessive-compulsive disorder symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG, near-infrared spectroscopy, eye tracking, MRI brain imaging, and other metrics;Changes in comorbid depressive and anxiety symptoms.; | — |
Countries
China
Contacts
Public ContactWeihui Li
Second Xiangya Hospital of CSU
Outcome results
None listed