Invasive fungal diseases
Conditions
Interventions
Observation group:None
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Chinese patients receiving triazoles (fluconazole, voriconazole, itraconazole, posaconazole, and isavuconazole) at least once for antifungal therapy.
Exclusion criteria
Exclusion criteria: 1.Patients with unavailable or incomplete prescription and administration records (including time of dosing and administration) of triazole treatments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with triazoles receiving TDM and target attainments for trough concentrations; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients with trough concentrations exceeding target range;Time from first dose to first TDM;Number of TDM for target attainment of trough concentrations;Time to target attainment of trough concentrations;Proportion of patients with at least one adjustment (e.g. dose, frequency) after first TDM;Target attainment with at least one adjustment after first TDM;All-cause inpatient mortality;Incidence of AESI;Overall response;Proportion of patients with AESI leading to treatment discontinuation;Clinical response; | — |
Countries
China
Contacts
Public ContactZhang Jing
Huashan Hospital, Fudan University
Outcome results
None listed