colorectal tumor
Conditions
Interventions
experimental group:Taking polyethylene glycol intestinal cleanser
control group:Take magnesium sodium potassium sulfate intestinal cleanser
Sponsors
Wuhan Puren Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. At the time of signing the informed consent form, participants must be between 45 and 75 years old (inclusive). 2. Participants scheduled for colorectal tumor screening or surveillance via colonoscopy.
Exclusion criteria
Exclusion criteria: 1. Individuals with contraindications to colonoscopy or oral methylene blue enteric-coated sustained-release tablets; 2. Pregnant or breastfeeding women; 3. Presence of significant CRC alarm symptoms or signs (e.g., hematochezia, melena, unexplained anemia, weight loss, abdominal mass, or positive digital rectal examination); 4. History of colorectal resection; 5. Known active inflammatory bowel disease (e.g., ulcerative colitis, Crohn’s disease) in acute exacerbation, or conditions that may hinder complete colonoscopy, such as severe colorectal stenosis, intestinal obstruction or suspected obstruction, toxic megacolon, gastric retention, or intestinal perforation; 6. Use of antiplatelet medications (e.g., aspirin or clopidogrel) within 7 days prior to colonoscopy; 7. Participants with confirmed G6PD deficiency; 8. Current use of selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants at screening; 9. Severe cardiovascular diseases (e.g., heart failure NYHA Class III-IV) or hepatic/renal insufficiency (e.g., eGFR <30 mL/min/1.73m², Child-Pugh Class C);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Methylene blue staining score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adenoma detection rate;Boston Bowel Preparation Scale, BBPS; | — |
Countries
China
Contacts
Public ContactHuang Linfei
Wuhan Puren Hospital
Outcome results
None listed