type 2 diabetes
Conditions
Interventions
FRC+Metformin group:Combination Preparations (FRC) plus Metformin Sustained-Release Tablets
GLP-1RAs+Metformin group:GLP-1RAs plus Metformin Sustained-Release Tablets
Metformin group + Placebo group:Metformin Extended-Release Tablets Placebo
Sponsors
Shanghai Pudong New Area People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18–75 years old; 2. FPG >= 11.1 mmol/L and/or HbA1c >= 9.0%; 3. BMI >= 24 kg/m^2; 4. Disease course: 0~12 months; 5. All three islet autoantibodies are negative; 6. No prior treatment with any hypoglycemic drugs.
Exclusion criteria
Exclusion criteria: 1. Patients with Type 1 diabetes mellitus and specific types of diabetes mellitus; 2. Patients complicated with acute complications of diabetes mellitus (DM), infection, severe hepatic and renal impairment, as well as cardiac insufficiency; 3. Patients with medullary thyroid carcinoma or multiple endocrine neoplasia type 2 combined with diabetes mellitus; 4. Patients with a history of pancreatitis; 5. Pregnant, lactating females or those with a pregnancy plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical remission of type 2 diabetes;Changes in pancreatic ß -cell function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in body weight; | — |
Countries
China
Contacts
Public ContactTaoqin
Shanghai Pudong New Area People's Hospital
Outcome results
None listed