Lumbar spinal stenosis
Conditions
Interventions
Paraspinal muscle sarcopenia group:None
Control group:None
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
Female
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Female patients aged =50 years. 2.Patients diagnosed with lumbar degenerative diseases and scheduled to undergo lumbar spine surgery. 3.Patients who can complete preoperative lumbar MRI, whole-spine standing radiographs, bioelectrical impedance analysis, and handgrip strength assessment. 4.Patients from whom a small amount of paraspinal muscle tissue can be obtained intraoperatively without altering the established surgical plan. 5.Patients who understand the study protocol and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of previous lumbar spine surgery. 2.Patients with liver cirrhosis or other severe chronic liver diseases. 3.Patients with active malignant tumors or a definite history of cachexia. 4.Patients with rheumatoid arthritis, systemic lupus erythematosus, inflammatory myopathy, or other active autoimmune diseases. 5.Patients with long-term use of medium to high doses of glucocorticoids. 6.Patients with recent active infection, or those with markedly elevated CRP or ESR that cannot be explained by lumbar degenerative disease. 7.Patients with uncontrolled severe endocrine or metabolic diseases, such as diabetes mellitus with HbA1c >8.0%, hyperthyroidism, or hypothyroidism. 8.Patients with neurological or primary muscular diseases, such as Parkinson’s disease, sequelae of stroke, muscular dystrophy, or myasthenia gravis. 10. Active cardiovascular diseases; 11. Severe renal insufficiency, severe cardiopulmonary insufficiency, or other conditions that the researcher deems unsuitable for inclusion in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of fatty infiltration of the multifidus muscle at the affected segment;Single-cell/single-nucleus RNA sequencing features of multifidus muscle tissue; | — |
Secondary
| Measure | Time frame |
|---|---|
| Preoperative laboratory test parameters;Systemic sarcopenia-related indicators;Preoperative pain and lumbar functional scores;Spinopelvic sagittal and coronal alignment parameters;Histopathological characteristics of multifidus muscle tissue;Clinical characteristics and disease-related features;Metabolomic features of multifidus muscle tissue and preoperative serum;Total and functional cross-sectional areas of the multifidus muscle at the affected segment; | — |
Countries
China
Contacts
Public ContactWang Hai
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed