Postoperative delirium
Conditions
Interventions
Group C: Remimazolam-induced maintenance group:Anesthesia induction and maintenance with remazolam besylate
Group B: Remimazolam-induced sevoflurane maintenance group
:Anesthesia induction with remazolam besylate and maintenance with sevoflurane
Group A: Etomidate induction, sevoflurane maintenance group
:Etomidate anesthesia induction and sevoflurane maintenance
Sponsors
Sichuan Provincial Orthopaedic Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The clinical data of the patients are accurate and complete in terms of collection and preservation. 2. There is no gender restriction. The age>= 65 years old, and BMI in the range of 18-30 kg/m^2. 3. The preoperative American Society of Anesthesiologists (ASA) classification should be grade I - III, and Mallampati airway classification should be grade I - III. 4.The operation time should be more than 0.5 hours. 5.The patients should have clearly understood the content of this study before the operation and voluntarily participated, and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who have been using psychotropic drugs and sedative and analgesic drugs for a long time, or those who are allergic to the study drugs or have contraindications for their use; 2. Patients with severe diseases of the circulatory system, respiratory system, endocrine system and liver-kidney functions; 3. Patients with abnormal cognitive function and communication disorders; 4. Patients who have unexpected events requiring emergency treatment during the operation, such as severe drug allergy, arrhythmia, etc., with operation time longer than 3 hours or blood loss more than 200 ml; 5.Patients who use sedative drugs after the operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic indicators;The prevalence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;QoR-40 Scale;Lipoprotein-associated phospholipaseA2 (Lp-PLA2);QoR-40 Scale;Central nervous system specific protein ß (S100ß); | — |
Countries
China
Contacts
Public ContactPeiyu Li
Sichuan Provincial Orthopaedic Hospital
Outcome results
None listed