Postoperative delirium
Conditions
Interventions
Ulinastatin combined with Ginkgo biloba extract group (UE group):Ulinastatin 5000 u/kg intravenously infused via pump over 15 min, and Ginkgo biloba extract injection 70 mg per dose added to 250 mL no
Control group (C group):Equal volume of normal saline intravenously administered at the same time points before incision and days 1-3 after surgery
Sponsors
Tianjin Jizhou District People’s Hospital
Eligibility
Sex/Gender
All
Age
70 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=70 years; 2. American Society of Anesthesiologists (ASA) physical status classification I-III; 3. Scheduled to undergo hip surgery under ultrasound-guided fascia iliaca compartment block combined with combined spinal-epidural anesthesia; 4. Preoperative hepatic and renal functions, acid-base balance, blood glucose, and serum electrolytes are within normal limits.
Exclusion criteria
Exclusion criteria: 1. Patients with current or previous central nervous system diseases; 2. Patients with active liver disease, or those who have previously undergone neurosurgery or cardiac surgery; 3. Patients who have used sedatives or antidepressants during the study period; 4. Patients with severe visual or auditory impairment, or those who are unable to understand Mandarin; 5. Patients who have previously been exposed to the same neuropsychological scales; 6. Patients with a preoperative Mini-Mental State Examination (MMSE) score of less than or equal to 24; 7. Patients with poor compliance or those who are unable to complete the trial in accordance with the study protocol; 8. Patients who have participated in other clinical drug trials within the past 4 weeks; 9. Patients who are deemed unsuitable for inclusion by the investigator for any reason.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Postoperative delirium incidence rate;Duration of postoperative delirium;Serum interleukin-6 (IL-6) level;Serum S100 calcium-binding protein B (S100ß) level;Postoperative delirium incidence rate and associated complications; | — |
Countries
China
Contacts
Public ContactWang Ruyi
Tianjin Jizhou District People’s Hospital
Outcome results
None listed