Keratoconus
Conditions
Interventions
Case Group:none
control group:none
Sponsors
Wuhan Aier Hankou Eye Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The keratoconus group: 1. Clinically diagnosed keratoconus (typical corneal topography findings: Kmax > 47.2 D, IS > 1.4); 2. Voluntary signing of the informed consent form; 3. KC patients with a history of allergies but currently in a stable phase (no acute inflammation and no medication use for at least one month); Healthy control group: 4. Matched to the case group in terms of age, sex, BMI and season of data collection; 5. No family history of keratoconus; 6. Normal corneal topography (Kmax < 47 D); 7. No other ocular diseases;
Exclusion criteria
Exclusion criteria: 1.Previous corneal surgery history (CXL, corneal transplantation, refractive surgery); 2.Other ocular comorbidities (glaucoma, cataract, high intraocular pressure, or other retinal diseases); 3.Active ocular infection or inflammation (e.g., acute phase of severe allergic conjunctivitis); 4.Long-term use of antibiotic or steroid eye drops; 5.Contact lens wearers (especially RGP lenses), must discontinue for at least 4 weeks; 6.Systemic diseases (diabetes, hypertension, autoimmune disorders); 7.Pregnancy or breastfeeding; 8.Use of vitamin D supplements within the past 3 months; 9.Excessive UV exposure or significant change in geographical latitude within the past month (season of sample collection should be recorded); 10.Use of systemic or topical corticosteroids within the past 3 months; 11.Diseases significantly affecting vitamin D metabolism (e.g., chronic kidney disease, cirrhosis, hyperparathyroidism);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Vitamin D;Tear inflammatory factors;VDR Genotype; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tear miRNA; | — |
Countries
China
Contacts
Public ContactQiao Chen
Wuhan Aier Hankou Eye Hospital
Outcome results
None listed