Postoperative delirium
Conditions
Interventions
Experimental Group:Patients received a slow bolus of low-dose esketamine at a dose of 0.1 mg/kg in the post-anesthesia care unit.
Control Group:The patient was given a slow intravenous bolus of saline of equivalent volume in the post-anesthesia care unit.
Sponsors
The first affiliated hospital of anhui medical university
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age older than 60 years; 2.ASA classification II-III; 3. Patients with elective non-cardiac, non-neurosurgical procedures;
Exclusion criteria
Exclusion criteria: 1. Patients with abnormal preoperative cognitive function (MoCA score = 180 / 100mmHg, history of intracerebral hemorrhage, recent cardiovascular events ( such as myocardial infarction in the past 6 months ), severe circulatory failure or shock decompensation, severe liver and kidney dysfunction, history of hypersensitivity to esketamine, ketamine or preparation excipients; 4.Patients with delayed emergence; 5.Chronic alcohol abuse or psychotropic drug use; 6. Ongoing participation in another clinical trial; 7.Decline to participate in the study and sign the informed consent form;
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Resting and exercise NRS score;30-day all-cause mortality rate;Cognitive function one month after surgery;Incidence of severe delirium;Post-operative extubation time;Improvement of disorientation in patients with apathy delirium during postoperative emergence period;Sleep quality score;The sum of the number of delirium-positive days in patients with delirium;Cumulative occurrence of POD;Duration of delirium;Postoperative anxiety-depression score;Incidence of complications after surgery;Time from the end of the operation to the appearance of delirium;Length of Stay after surgery;Postoperative cognitive impairment (POCD) on the 5th day after surgery or at the time of discharge (if earlier); | — |
Primary
| Measure | Time frame |
|---|---|
| Incidence of Hypoactive Emergence Delirium;Incidence of postoperative delirium; | — |
Countries
China
Contacts
Public ContactCheng Xinqi
The first affiliated hospital of anhui medical university
Outcome results
None listed