Emergence Agitation (EA)
Conditions
Interventions
Esketamine group:Intravenous esketamine (0.5 mg/kg) was administered during anesthetic induction.
Propofol group:Intravenous propofol (2 mg/kg) was administered during anesthetic induction.
Sponsors
School of Stomatology , The Fourth Military Medical University
Eligibility
Sex/Gender
All
Age
5 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Age 5–12 years, either sex; 2. American Society of Anesthesiologists (ASA) physical status I–II; 3. Scheduled for supernumerary tooth extraction under laryngeal mask airway general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Known difficult airway or Mallampati classification = grade III; 2. Upper respiratory tract infection; 3. Developmental or psychiatric disorders; 4. Obesity (BMI > 30 kg/m²); 5. Hepatic or renal insufficiency; 6. Known allergy to esketamine, propofol, egg, or soy; 7. Recent exposure to major life events (e.g., parental divorce, bereavement, relocation, or school transfer); 8. Use of analgesic or sedative medications within 48 hours prior to surgery; 9. History of previous anesthesia-related complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of emergence agitation;Time-weighted mean agitation load;Time to first emergence agitation episode; | — |
Secondary
| Measure | Time frame |
|---|---|
| LMA removal time;Time to emergence;PACU stay duration;Time to discharge readiness;Agitation duration;Requirement for rescue sedatives;FLACC score and proportion of moderate-to-severe pain (FLACC score = 4).;Analgesic requirement hierarchy;Incidence of rescue analgesia;Self-injurious scratching;Spontaneous breathing maintenance;Postoperative recovery quality indicators;Parental satisfaction;Clinician satisfaction;Postoperative telephone follow-up at 24 hours;Safety outcomes; | — |
Countries
China
Contacts
Public ContactZhang Yaqiu
School of Stomatology , The Fourth Military Medical University
Outcome results
None listed