Valvular Heart Disease
Conditions
Interventions
Control group with normal cardiac structure and function:none
Sponsors
The first affiliated hospital of anhui medical university
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients requiring valve replacement surgery are enrolled in the valvular heart disease group; 2.the control group comprises patients with normal cardiac function, ASA class I–II, undergoing elective surgery.
Exclusion criteria
Exclusion criteria: 1.This study strictly excludes patients with a history of neurological diseases (epilepsy, stroke, severe traumatic brain injury), severe psychiatric disorders (e.g., schizophrenia), long-term use of psychoactive drugs or sedatives, history of substance abuse, severe hepatic or renal insufficiency (Child-Pugh class C, eGFR < 30 ml/min), allergy to sevoflurane, prior brain radiotherapy or chemotherapy, inability to cooperate with EEG monitoring, or pregnancy/lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimum Alveolar Concentration for Awake (MACawake) of Sevoflurane; | — |
Secondary
| Measure | Time frame |
|---|---|
| Power spectrum of each frequency band; | — |
Countries
China
Contacts
Public ContactYu Mao
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed