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A study on the brain network remodeling mechanism of premenstrual syndrome regulated by HD-tDCS based on the thalamus-prefrontal cortex circuit

A study on the brain network remodeling mechanism of premenstrual syndrome regulated by HD-tDCS based on the thalamus-prefrontal cortex circuit

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600128210
Enrollment
Unknown
Registered
2026-07-15
Start date
2026-07-15
Completion date
Unknown
Last updated
2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premenstrual syndrome (PMS)

Interventions

HC group:Randomly receive three different stimulation patterns of HD-tDCS
mPFC group:HD-tDCS intervention targeting both sides of the mPFC
Sham group:Fake stimulation
DLPFC group:HD-tDCS

Sponsors

The People’s Hospital of Guangxi Zhuang Autonomous Region
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. PMS Inclusion Criteria: (1) Meet the diagnostic criteria for PMS; (2) Regular menstrual cycle, cycle length 21-35 days; (3) Age between 18 and 45; (4) No concurrent medication or other clinically relevant treatments during the study. 2. HC Inclusion Criteria: (1) Do not meet the diagnostic criteria for PMS; (2) Regular menstrual cycle, cycle length 21-35 days; (3) Age between 18 and 45; (4) No concurrent medication or other clinically relevant treatments during the study.

Exclusion criteria

Exclusion criteria: 1. PMS exclusion criteria: people with other mental disorders or those dependent on drugs or alcohol; 2. Those with physical diseases, recent head trauma, serious infections, or surgeries; 3. Pregnant or breastfeeding women; 4. Patients with irregular menstrual cycles; 5. Participants in other clinical drug studies; 6. People with a history of smoking; 7. Patients with polycystic ovary syndrome or endometriosis.

Design outcomes

Primary

MeasureTime frame
Daily Record of Severity of Problems (DRSP) ;sMRI;SANDI;

Countries

China

Contacts

Public ContactGaoxiong Duan

The People’s Hospital of Guangxi Zhuang Autonomous Region

duangaoxiong@126.com+86 771 572 2439

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026